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As the false lumen expands, it can lead to severe complications such as aortic valve insufficiency, pericardial tamponade, or even rupture of the aorta

The way mitochondrial dysfunction likely becomes more manifest in ME/CFS is when symptoms are provoked and de novo energy production is required Its not that the mitochondria are not involved they are but the mitochondrial problems are secondary to the neuroinflammation and oxidative stress thats present

Brown adipose tissue (BAT), a specialized form of adipose tissue, can uncouple cellular respiration from ATP production

IL-1 inhibits insulin release and processing of proinsulin into insulin, impairing glucose metabolism [569]